Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process.
نویسندگان
چکیده
A catalytic enantioselective bromocyclization of olefinic amides using amino-thiocarbamates as the catalysts has been developed. The resulting enantioenriched 2-substituted 3-bromopiperidines can readily be transformed to 3-substituted piperidines through a silver salt-mediated rearrangement. This process has been applied to the synthesis of a dopaminergic drug, Preclamol.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 49 39 شماره
صفحات -
تاریخ انتشار 2013